In a mixing bowl, blend cream cheese and mayo until smooth.
Stir in cheddar and pepper jack.
Fold in roasted red peppers, green chilis, jalapeños, cilantro, and (if using) pickled red onions.
Add taco seasoning, smoked paprika, lime juice, tequila, and Cholula. Mix well.
Season to taste with salt and pepper.
Chill for 30 minutes or more.
Right before serving, sprinkle Tajín on top.